The Effect of HOCl on Blepharitis
In summary, the study found that the HOCl group, treated with ultrasonic atomization for 5 minutes per eye, showed significant improvement in lid margin redness, along with a notable reduction in conjunctival redness and corneal fluorescein staining (CFS) compared to the control group. After two weeks of treatment, HOCl proved to be both effective and safe for managing blepharitis.
The main goal of treating blepharitis is to relieve symptoms. One way to measure how well a treatment works is by using the Ocular Surface Disease Index (OSDI), which helps assess eye discomfort and dryness.
In this study, patients using hypochlorous acid (HOCl) spray experienced a greater improvement in their symptoms compared to the control group. Specifically, their OSDI scores improved by an average of 20.3 points, while the control group only improved by 9.6 points. This suggests that HOCl is significantly more effective at reducing symptoms.
These findings are consistent with previous research showing that HOCl spray improved patients' quality of life after eye injections and provided symptom relief for dry eye patients over 30 days.
Although the exact cause of blepharitis is not fully understood, it is known that excess bacteria on the eyelids can trigger inflammation and irritation. HOCl helps by killing bacteria and reducing inflammation, making it a promising treatment option for blepharitis. Several previous studies identified the ocular safety profile of HOCL , and one reported that 0.01% was of the highest degree of patients’ comfort among several eyelid cleansers.
https://www.researchgate.net/publication/368227887_Effect_of_Hypochlorous_Acid_on_Blepharitis_through_Ultrasonic_Atomization_A_Randomized_Clinical_Trial